Title : Enhancement of fibroblast collagenase (matrix metalloproteinase-1) gene expression by ceramide is mediated by extracellular signal-regulated and stress-activated protein kinase pathways.

Pub. Date : 1998 Feb 27

PMID : 9478967






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Inflammatory cytokines tumor necrosis factor-alpha and interleukin-1 trigger the ceramide signaling pathway, initiated by neutral sphingomyelinase-elicited hydrolysis of cell membrane phospholipid sphingomyelin to ceramide, a new lipid second messenger. Sphingomyelins tumor necrosis factor Homo sapiens