Title : Transient 5-oxoprolinuria (pyroglutamic aciduria) with systemic acidosis in an adult receiving antibiotic therapy.

Pub. Date : 1998 Feb

PMID : 9474033






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1 We suggest that this patient developed a transient disturbance in the gamma-glutamyl cycle involving the 5-oxoprolinase step, which resulted in accumulation of 5-oxoproline that caused a severe high anion gap metabolic acidosis. Pyrrolidonecarboxylic Acid 5-oxoprolinase, ATP-hydrolysing Homo sapiens