Title : Analysis of chimeric proteins identifies the regions in the carbohydrate recognition domains of rat lung collectins that are essential for interactions with phospholipids, glycolipids, and alveolar type II cells.

Pub. Date : 1998 Feb 20

PMID : 9468543






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 In contrast, SP-D binds to phosphatidylinositol (PI) and glucosylceramide (GlcCer). Glucosylceramides surfactant protein D Rattus norvegicus
2 In contrast, SP-D binds to phosphatidylinositol (PI) and glucosylceramide (GlcCer). Glucosylceramides surfactant protein D Rattus norvegicus
3 From these results, we conclude that 1) the SP-A region of Glu195-Phe228 is required for lipid and type II cell interactions, 2) the SP-D region of Cys261-Phe355 is required for optimal lipid interactions, and 3) the structural requirement for the binding of SP-D to PI is different from that for GlcCer. Glucosylceramides surfactant protein D Rattus norvegicus