Pub. Date : 1998 Jan 9
PMID : 9468299
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Here we report on a differential effect of suramin on PKCmu and various PKC isoforms representing the cPKC, nPKC, and aPKC group of the PKC family. | Suramin | protein kinase C zeta | Homo sapiens |
| 2 | In the absence of any cofactors suramin activates all PKC isoforms in the order of aPKCzeta >> PKCmu > cPKC, nPKCdelta. | Suramin | protein kinase C zeta | Homo sapiens |
| 3 | As judged by the Vmax/KM ratios (0.5 for PKCmu and 2.2 for PKCzeta) the substrate syntide 2 is phosphorylated by suramin-activated PKCzeta around four times more effectively than by suramin-activated PKCmu. | Suramin | protein kinase C zeta | Homo sapiens |
| 4 | As judged by the Vmax/KM ratios (0.5 for PKCmu and 2.2 for PKCzeta) the substrate syntide 2 is phosphorylated by suramin-activated PKCzeta around four times more effectively than by suramin-activated PKCmu. | Suramin | protein kinase C zeta | Homo sapiens |
| 5 | As judged by the Vmax/KM ratios (0.5 for PKCmu and 2.2 for PKCzeta) the substrate syntide 2 is phosphorylated by suramin-activated PKCzeta around four times more effectively than by suramin-activated PKCmu. | Suramin | protein kinase C zeta | Homo sapiens |
| 6 | Suramin-activated PKCmu behaves like that activated by phosphatidylserine and the phorbol ester TPA regarding autophosphorylation and differential inhibition by the PKC inhibitors Go 6976 and Go 6983. | Suramin | protein kinase C zeta | Homo sapiens |
| 7 | In the presence of activating cofactors, such as phosphatidylserine and TPA or cholesterol sulfate (for PKCzeta), the activity of the aPKCzeta is further stimulated, PKCmu is not significantly affected, and the cPKCs and the nPKCdelta are strongly inhibited by suramin. | Suramin | protein kinase C zeta | Homo sapiens |
| 8 | The differential action of suramin on PKC isoenzymes might play a role in some of its biological effects, as for instance inhibition of proliferation and tumor development. | Suramin | protein kinase C zeta | Homo sapiens |
| 9 | Moreover, due to this property suramin will possibly be a valuable tool for discriminating the activities of PKC isoenzymes in vitro and in vivo. | Suramin | protein kinase C zeta | Homo sapiens |