Title : Development validation and problems with the toxic equivalency factor approach for risk assessment of dioxins and related compounds.

Pub. Date : 1998 Jan

PMID : 9464894






6 Functional Relationships(s)
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1 Thus, the toxic equivalency factor (TEF) approach for HAH is based on the common mechanism of action for TCDD and related compounds in which a TEF value for a "dioxin-like" congener is defined as the potency of the individual (i) congener relative to TCDD ([EC50 [TCDD]/EC50 [test compound]). Polychlorinated Dibenzodioxins TEF transcription factor, PAR bZIP family member Homo sapiens
2 Thus, the toxic equivalency factor (TEF) approach for HAH is based on the common mechanism of action for TCDD and related compounds in which a TEF value for a "dioxin-like" congener is defined as the potency of the individual (i) congener relative to TCDD ([EC50 [TCDD]/EC50 [test compound]). Polychlorinated Dibenzodioxins TEF transcription factor, PAR bZIP family member Homo sapiens
3 Thus, the toxic equivalency factor (TEF) approach for HAH is based on the common mechanism of action for TCDD and related compounds in which a TEF value for a "dioxin-like" congener is defined as the potency of the individual (i) congener relative to TCDD ([EC50 [TCDD]/EC50 [test compound]). Polychlorinated Dibenzodioxins TEF transcription factor, PAR bZIP family member Homo sapiens
4 Thus, the toxic equivalency factor (TEF) approach for HAH is based on the common mechanism of action for TCDD and related compounds in which a TEF value for a "dioxin-like" congener is defined as the potency of the individual (i) congener relative to TCDD ([EC50 [TCDD]/EC50 [test compound]). Polychlorinated Dibenzodioxins TEF transcription factor, PAR bZIP family member Homo sapiens
5 Thus, the toxic equivalency factor (TEF) approach for HAH is based on the common mechanism of action for TCDD and related compounds in which a TEF value for a "dioxin-like" congener is defined as the potency of the individual (i) congener relative to TCDD ([EC50 [TCDD]/EC50 [test compound]). Polychlorinated Dibenzodioxins TEF transcription factor, PAR bZIP family member Homo sapiens
6 Thus, the toxic equivalency factor (TEF) approach for HAH is based on the common mechanism of action for TCDD and related compounds in which a TEF value for a "dioxin-like" congener is defined as the potency of the individual (i) congener relative to TCDD ([EC50 [TCDD]/EC50 [test compound]). Polychlorinated Dibenzodioxins TEF transcription factor, PAR bZIP family member Homo sapiens