Title : Ligation of the alpha2M signaling receptor with receptor-recognized forms of alpha2-macroglobulin initiates protein and DNA synthesis in macrophages. The effect of intracellular calcium.

Pub. Date : 1998 Jan 2

PMID : 9459492






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 We have previously reported that receptor-recognized forms of the proteinase inhibitor alpha2-macroglobulin (alpha2M) bind to a distinct receptor (alpha2MSR), Kd approximately 50-100 pM, activating a signaling cascade, triggering tyrosine phosphorylation of phospholipase Cgamma1, and raising cytosolic pH. Tyrosine alpha-2-macroglobulin Homo sapiens
2 We have previously reported that receptor-recognized forms of the proteinase inhibitor alpha2-macroglobulin (alpha2M) bind to a distinct receptor (alpha2MSR), Kd approximately 50-100 pM, activating a signaling cascade, triggering tyrosine phosphorylation of phospholipase Cgamma1, and raising cytosolic pH. Tyrosine alpha-2-macroglobulin Homo sapiens