Pub. Date : 1998 Feb 6
PMID : 9452447
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We observe that hyperglycemic levels of D-glucose (8-20 mM) inhibit the release of IL-1 by lipopolysaccharide-stimulated RAW 264.7 murine macrophage cells. | Glucose | interleukin 1 complex | Mus musculus |
| 2 | An inhibitor of glucose transport and metabolism, 2-deoxyglucose, prevents this inhibition of IL-1 release. | Glucose | interleukin 1 complex | Mus musculus |
| 3 | Immunoprecipitation and activity measurements demonstrate that high glucose levels block the release of IL-1 but do not inhibit IL-1 production. | Glucose | interleukin 1 complex | Mus musculus |
| 4 | Phorbol 12-myristate 13-acetate, an agonist of PKC, mimics glucose-induced inhibition of IL-1 release. | Glucose | interleukin 1 complex | Mus musculus |
| 5 | These results demonstrate that high glucose levels inhibit IL-1 release (but not production) by RAW 264. | Glucose | interleukin 1 complex | Mus musculus |