Pub. Date : 1998 Feb
PMID : 9447979
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | To test this idea, we inactivated the GTPase activity of Ypt1p by using the Q67L mutation, which targets a conserved residue that helps catalyze GTP hydrolysis in Ras. | Guanosine Triphosphate | RAB1A, member RAS oncogene family | Homo sapiens |
| 2 | We demonstrate that the mutant Ypt1-Q67L protein is severely impaired in its ability to hydrolyze GTP both in the absence and in the presence of GAP and consequently is restricted mostly to the GTP-bound form. | Guanosine Triphosphate | RAB1A, member RAS oncogene family | Homo sapiens |
| 3 | We demonstrate that the mutant Ypt1-Q67L protein is severely impaired in its ability to hydrolyze GTP both in the absence and in the presence of GAP and consequently is restricted mostly to the GTP-bound form. | Guanosine Triphosphate | RAB1A, member RAS oncogene family | Homo sapiens |
| 4 | These results suggest that the function of Ypt1p in vesicular transport requires not only the GTP-bound form of the protein but also the interaction of Ypt1p with its GNEF. | Guanosine Triphosphate | RAB1A, member RAS oncogene family | Homo sapiens |