Title : Influence of the cytosolic carboxyl termini of human B1 and B2 kinin receptors on receptor sequestration, ligand internalization, and signal transduction.

Pub. Date : 1998 Jan 30

PMID : 9446564






3 Functional Relationships(s)
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1 Incubation of [3H]BK at 37 degrees C with cells expressing wild type B2KR resulted in pronounced and rapid ligand internalization ( approximately 80% after 10 min). Tritium kininogen 1 Homo sapiens
2 Truncation of the B2KR up to Lys315 almost completely abolished internalization of [3H]BK (10% after 10 min). Tritium kininogen 1 Homo sapiens
3 This additional reduction is apparently not caused by the loss of the potential palmitoylation site at Cys324, since a B2KR with a point mutation of Cys324 to Ala internalized [3H]BK as rapidly as the wild type B2KR. Tritium kininogen 1 Homo sapiens