Title : Use of D-myo inositol 1,2,6 trisphosphate to inhibit contractile activity in rat ventricular cardiomyocytes induced by neuropeptide Y and other cardioactive peptides through phospholipase C.

Pub. Date : 1997 Dec

PMID : 9422811






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 NPY alone does not influence the basal level of contraction of cardiomyocytes, but can attenuate isoprenaline-stimulated contraction and can increase contractile amplitude from basal when the transient outward current is blocked with 4-aminopyridine. Isoproterenol neuropeptide Y Rattus norvegicus
2 In the presence of isoprenaline (100 nM), the negative response to NPY (100 nM) was attenuated significantly by pp56 (1-100 microM). Isoproterenol neuropeptide Y Rattus norvegicus