Title : Inhibition of cyclic GMP phosphodiesterases augments renal responses to atrial natriuretic factor in congestive heart failure.

Pub. Date : 1994 Oct

PMID : 9420635






2 Functional Relationships(s)
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1 In separate groups of dogs, low-dose intrarenal cGMP PDI potentiated the actions of exogenous ANF on glomerular filtration and distal nephron sodium reabsorption, leading to enhanced natriuresis in the presence or absence of severe CHF. Sodium natriuretic peptide A Canis lupus familiaris
2 These studies support a link between ANF and the renal actions of cGMP PDI, and indicate that cGMP phosphodiesterases may contribute to sodium retention in advanced CHF by limiting the renal actions of increased endogenous ANF. Sodium natriuretic peptide A Canis lupus familiaris