Title : Colocalization of Ras and Ral on the membrane is required for Ras-dependent Ral activation through Ral GDP dissociation stimulator.

Pub. Date : 1997 Dec 11

PMID : 9416833






8 Functional Relationships(s)
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1 Colocalization of Ras and Ral on the membrane is required for Ras-dependent Ral activation through Ral GDP dissociation stimulator. Guanosine Diphosphate RAS like proto-oncogene A Homo sapiens
2 Colocalization of Ras and Ral on the membrane is required for Ras-dependent Ral activation through Ral GDP dissociation stimulator. Guanosine Diphosphate RAS like proto-oncogene A Homo sapiens
3 Colocalization of Ras and Ral on the membrane is required for Ras-dependent Ral activation through Ral GDP dissociation stimulator. Guanosine Diphosphate RAS like proto-oncogene A Homo sapiens
4 Ral GDP dissociation stimulator (RalGDS), a putative effector protein of Ras, stimulated the GDP/GTP exchange reaction of the post-tanslationally lipid-modified but not the unmodified form of Ral in response to epidermal growth factor in COS cells. Guanosine Diphosphate RAS like proto-oncogene A Homo sapiens
5 When Ral was incorporated with the GTP-bound form of Ras in the liposomes, RalGDS stimulated the dissociation of GDP from Ral, while the GDP-bound form of Ras did not affect the RalGDS action. Guanosine Diphosphate RAS like proto-oncogene A Homo sapiens
6 When Ral was incorporated with the GTP-bound form of Ras in the liposomes, RalGDS stimulated the dissociation of GDP from Ral, while the GDP-bound form of Ras did not affect the RalGDS action. Guanosine Diphosphate RAS like proto-oncogene A Homo sapiens
7 When Ral was incorporated with the GTP-bound form of Ras in the liposomes, RalGDS stimulated the dissociation of GDP from Ral, while the GDP-bound form of Ras did not affect the RalGDS action. Guanosine Diphosphate RAS like proto-oncogene A Homo sapiens
8 Rap, which shared the same effector loop as Ras, also stimulated the dissociation of GDP from Ral through RalGDS in the liposomes, although Rap did not enhance the RalGDS action in COS cells. Guanosine Diphosphate RAS like proto-oncogene A Homo sapiens