Title : The role of motilin and cisapride in the enteric nervous system of the lower esophageal sphincter in humans.

Pub. Date : 1997

PMID : 9413048






1 Functional Relationships(s)
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1 The findings of this study revealed that: cholinergic nerves are mainly involved in the regulation of enteric nerves in the steady state, while non-adrenergic non-cholinergic (NANC) inhibitory nerves also exist; motilin may act both via nerves and also directly on the LES smooth muscle; and cisapride releases acetylcholine from the end of the postganglionic fiber of the cholinergic nerve in human LES thereby inducing contraction of the LES. Cisapride motilin Homo sapiens