Title : Copper ions promote peroxidation of low density lipoprotein lipid by binding to histidine residues of apolipoprotein B100, but they are reduced at other sites on LDL.

Pub. Date : 1997 Nov

PMID : 9409331






3 Functional Relationships(s)
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1 Copper ions promote peroxidation of low density lipoprotein lipid by binding to histidine residues of apolipoprotein B100, but they are reduced at other sites on LDL. Histidine apolipoprotein B Homo sapiens
2 In the current studies, we used diethylpyrocarbonate (DEPC) to modify the histidine residues of apolipoprotein B100, the major protein in LDL. Histidine apolipoprotein B Homo sapiens
3 These observations suggest that peroxidation of the lipids in LDL can proceed with normal kinetics only when Cu2+ binds preferentially to sites on apolipoprotein B100 that contain histidine residues. Histidine apolipoprotein B Homo sapiens