Title : Oxidative DNA damage in CD34+ myelodysplastic cells is associated with intracellular redox changes and elevated plasma tumour necrosis factor-alpha concentration.

Pub. Date : 1997 Dec

PMID : 9401076






2 Functional Relationships(s)
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1 Using single-cell gel electrophoresis, we have identified oxidized pyrimidine nucleotides in the progenitor-enriched bone marrow CD34+ compartment from MDS patients (P=0.039), which are absent in both CD34- MDS cells (P=0.53) and also CD34+ cells from normal subjects (P=0.55). Pyrimidine Nucleotides CD34 molecule Homo sapiens
2 MDS CD34+ blood cells also showed oxidized pyrimidine nucleotides compared with CD34- cells (P=0.029). Pyrimidine Nucleotides CD34 molecule Homo sapiens