Pub. Date : 1995 Jun
PMID : 9398947
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Time course effects of vanadium supplement on cytosolic reduced glutathione level and glutathione S-transferase activity. | Vanadium | hematopoietic prostaglandin D synthase | Rattus norvegicus |
| 2 | The influence of vanadium, an important dietary micronutrient, was evaluated on the cytosolic reduced glutathione (GSH) content and glutathione S-transferase (GST) activity in several rat target tissues. | Vanadium | hematopoietic prostaglandin D synthase | Rattus norvegicus |
| 3 | Supplementation of drinking water with vanadium at the level of 0.2 or 0.5 ppm for 4, 8, or 12 wk was found to increase the GSH level with a concomitant elevation in GST activity in the liver followed by small intestine mucosa, large intestine mucosa, and kidney. | Vanadium | hematopoietic prostaglandin D synthase | Rattus norvegicus |
| 4 | The levels of vanadium that were found to increase the content of GSH and activity of GST in the liver, intestine, and kidney did not exert any toxic manifestation as evidenced from water and food consumption as well as the growth responses of the experimental animals. | Vanadium | hematopoietic prostaglandin D synthase | Rattus norvegicus |
| 5 | All these results clearly indicate that vanadium under the doses employed in our study has a significant inducing role on GSH content with a concurrent elevation in GST activity in the liver and specific extrahepatic tissues without any apparent sign of cytotoxicity. | Vanadium | hematopoietic prostaglandin D synthase | Rattus norvegicus |
| 6 | In addition, since the ability to afford an increment in the endogenous GSH-GST pool by anticarcinogenic natural substances has been found to correlate with their activity to inhibit neoplastic transformation, the trace element vanadium may be considered as a novel anticancer agent. | Vanadium | hematopoietic prostaglandin D synthase | Rattus norvegicus |