Pub. Date : 1997 Dec
PMID : 9398726
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Because the cytotoxic T lymphocyte antigen 4 (CTLA4) alanine-17 encoded by the CTLA4 gene on chromosome 2q33 confers susceptibility to Graves" disease, as well as to type 1 (insulin-dependent) diabetes mellitus, we investigated this dimorphism in the other endocrine autoimmune disorders: Hashimoto"s thyroiditis and Addison"s disease. | Alanine | cytotoxic T-lymphocyte associated protein 4 | Homo sapiens |
| 2 | Because the cytotoxic T lymphocyte antigen 4 (CTLA4) alanine-17 encoded by the CTLA4 gene on chromosome 2q33 confers susceptibility to Graves" disease, as well as to type 1 (insulin-dependent) diabetes mellitus, we investigated this dimorphism in the other endocrine autoimmune disorders: Hashimoto"s thyroiditis and Addison"s disease. | Alanine | cytotoxic T-lymphocyte associated protein 4 | Homo sapiens |
| 3 | Because the cytotoxic T lymphocyte antigen 4 (CTLA4) alanine-17 encoded by the CTLA4 gene on chromosome 2q33 confers susceptibility to Graves" disease, as well as to type 1 (insulin-dependent) diabetes mellitus, we investigated this dimorphism in the other endocrine autoimmune disorders: Hashimoto"s thyroiditis and Addison"s disease. | Alanine | cytotoxic T-lymphocyte associated protein 4 | Homo sapiens |
| 4 | In conclusion, an alanine at codon 17 of CTLA4 confers genetic susceptibility to Hashimoto"s thyroiditis, whereas this applies only to the subgroup of DQA1*0501+ patients with Addison"s disease. | Alanine | cytotoxic T-lymphocyte associated protein 4 | Homo sapiens |