Title : Pretranslational and posttranslational regulation of rat hepatic CYPs 3A2 and 2E1 by disulfiram.

Pub. Date : 1997 Dec 15

PMID : 9393675






2 Functional Relationships(s)
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1 It was found that CYP2E1-mediated aniline 4-hydroxylase activity was weakly inhibited by DS in vitro, but that preincubation of the drug with NADPH-supplemented microsomes to generate metabolites of DS enhanced the extent of inhibition somewhat. Disulfiram cytochrome P450, family 2, subfamily e, polypeptide 1 Rattus norvegicus
2 It was found that CYP2E1-mediated aniline 4-hydroxylase activity was weakly inhibited by DS in vitro, but that preincubation of the drug with NADPH-supplemented microsomes to generate metabolites of DS enhanced the extent of inhibition somewhat. Disulfiram cytochrome P450, family 2, subfamily e, polypeptide 1 Rattus norvegicus