Title : Structural changes of the sarcoplasmic reticulum Ca(II)-ATPase nucleotide binding domain by pH and La(III).

Pub. Date : 1997 Dec 1

PMID : 9390185






2 Functional Relationships(s)
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1 Here, we study the accessibility of the fluorescein covalently attached to the Lys515 at the nucleotide binding domain of the ATPase to the small collisional quencher iodide at pH 6 and 8, as well as the effect of ligand binding (La3+, La(3+)-nucleotide, and Ca2+). lanthanum(3+) dynein axonemal heavy chain 8 Homo sapiens
2 Taken together, these findings show the presence of structural flexibility in the FITC binding site and suggest a structural modulation of the Ca(2+)-ATPase nucleotide binding domain by pH and La3+ binding through long-range link-age mechanisms. lanthanum(3+) dynein axonemal heavy chain 8 Homo sapiens