Title : Critical role of asparagine 1065 of human alpha2-macroglobulin in formation and reactivity of the thiol ester.

Pub. Date : 1997 Dec 5

PMID : 9388263






1 Functional Relationships(s)
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1 It has been shown that the relative reaction preference of the C4 thiol ester toward oxygen and nitrogen nucleophiles upon activation by proteinase depends on whether residue 1106 is aspartate or histidine (Dodds, A. W., Ren, X.-D., Willis, A. C., and Law, S. K. A. Histidine renin Homo sapiens