Title : Neurosteroid coadministration prevents development of tolerance and augments recovery from benzodiazepine withdrawal anxiety and hyperactivity in mice.

Pub. Date : 1997 Jul-Aug

PMID : 9385589






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Long-term treatment of mice with full allosteric modulator (triazolam 0.25 mg/kg/day for 8 days) or selective allosteric modulator (diazepam 20 mg/kg/day for 21 days) of GABAA receptor induced tolerance to behavioral sedation on actimeter and anxiolytic effects on plus-maze, and produced a marked withdrawal anxiety and hyperactivity syndrome upon abrupt cessation of treatment, respectively. Diazepam gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1 Mus musculus