Pub. Date : 1995 Mar
PMID : 9383417
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Rapamycin, ascomycin and FK506 have a common domain responsible for binding to FKBP12, their cellular receptor, and different effector domains that determine the target of the complex. | Tacrolimus | FKBP prolyl isomerase 1A pseudogene 1 | Homo sapiens |
| 2 | CONCLUSIONS: The designed rapamycin-based FKBP12 ligand exhibits powerful binding properties but, unlike rapamycin, shows no activity in IL-6 dependent B-cell proliferation and, in contrast to FK506, shows no activity in the IL-2 reporter assay. | Tacrolimus | FKBP prolyl isomerase 1A pseudogene 1 | Homo sapiens |