Pub. Date : 1997
PMID : 9381979
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The above data indicate that LY335979 displays the following characteristics of an "ideal modulator" of Pgp-mediated multidrug resistance: high affinity binding to Pgp, high potency for in vitro reversal of drug resistance, high therapeutic index (activity was demonstrated at doses ranging from 1-30 mg/kg) observed in in vivo antitumor efficacy experiments, and a lack of pharmacokinetic interactions that alter the plasma concentration of coadministered oncolytic agents. | zosuquidar trihydrochloride | phosphoglycolate phosphatase | Homo sapiens |
| 2 | The above data indicate that LY335979 displays the following characteristics of an "ideal modulator" of Pgp-mediated multidrug resistance: high affinity binding to Pgp, high potency for in vitro reversal of drug resistance, high therapeutic index (activity was demonstrated at doses ranging from 1-30 mg/kg) observed in in vivo antitumor efficacy experiments, and a lack of pharmacokinetic interactions that alter the plasma concentration of coadministered oncolytic agents. | zosuquidar trihydrochloride | phosphoglycolate phosphatase | Homo sapiens |