Title : The effects of dexamethasone and chlorpromazine on tumour necrosis factor-alpha, interleukin-1 beta, interleukin-1 receptor antagonist and interleukin-10 in human volunteers.

Pub. Date : 1997 Aug

PMID : 9378493






2 Functional Relationships(s)
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1 Chlorpromazine and dexamethasone protect mice against lethal endotoxaemia by decreasing circulating concentrations of TNF-alpha and IL-1 beta. Chlorpromazine interleukin 1 beta Mus musculus
2 In conclusion, chlorpromazine inhibits TNF-alpha and IL-1 beta production in mice at concentrations that cannot be reached in humans, thus precluding its usage in clinical anti-cytokine strategies. Chlorpromazine interleukin 1 beta Mus musculus