Title : Comparison of two independent crystal structures of human dihydrofolate reductase ternary complexes reduced with nicotinamide adenine dinucleotide phosphate and the very tight-binding inhibitor PT523.

Pub. Date : 1997 Nov 11

PMID : 9374868






1 Functional Relationships(s)
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1 There are also significant differences in the conformation of the adenine-ribose moiety of NADPH in both complexes that differ from that observed for other inhibitor-NADPH-hDHFR ternary complexes. Ribose dihydrofolate reductase Homo sapiens