Title : Interleukin-2 and -4 induce resistance of granulocyte-macrophage colony-stimulating factor to corticosteroids.

Pub. Date : 1997 Sep 10

PMID : 9369357






2 Functional Relationships(s)
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1 In vitro steroid resistance was induced by 48 h pretreatment of mononuclear blood cells from healthy individuals (n = 10) with interleukin-2 and interleukin-4 (500 Units (U)/ml). Steroids interleukin 2 Homo sapiens
2 The results highlight the importance of interleukin-2 and interleukin-4 in the induction of steroid resistance, since pretreatment of mononuclear blood cells with these cytokines impaired corticosteroid inhibition of GM-CSF production. Steroids interleukin 2 Homo sapiens