Pub. Date : 1997 Dec 1
PMID : 9364061
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Estradiol enhances prostaglandin E2 receptor gene expression in luteinizing hormone-releasing hormone (LHRH) neurons and facilitates the LHRH response to PGE2 by activating a glia-to-neuron signaling pathway. | Estradiol | gonadotropin releasing hormone 1 | Mus musculus |
| 2 | Estradiol enhances prostaglandin E2 receptor gene expression in luteinizing hormone-releasing hormone (LHRH) neurons and facilitates the LHRH response to PGE2 by activating a glia-to-neuron signaling pathway. | Estradiol | gonadotropin releasing hormone 1 | Mus musculus |
| 3 | Estradiol enhances prostaglandin E2 receptor gene expression in luteinizing hormone-releasing hormone (LHRH) neurons and facilitates the LHRH response to PGE2 by activating a glia-to-neuron signaling pathway. | Estradiol | gonadotropin releasing hormone 1 | Mus musculus |
| 4 | In rodents, this facilitatory effect requires previous exposure to estradiol, suggesting that the steroid affects downstream components in the cascade that leads to PGE2-induced LHRH release. | Estradiol | gonadotropin releasing hormone 1 | Mus musculus |
| 5 | Thus, one mechanism by which estradiol facilitates the effect of neurotransmitters acting via PGE2 to stimulate LHRH release is by enhancing the glial production of substances that upregulate PGE2 receptors on LHRH neurons. | Estradiol | gonadotropin releasing hormone 1 | Mus musculus |
| 6 | Thus, one mechanism by which estradiol facilitates the effect of neurotransmitters acting via PGE2 to stimulate LHRH release is by enhancing the glial production of substances that upregulate PGE2 receptors on LHRH neurons. | Estradiol | gonadotropin releasing hormone 1 | Mus musculus |