Title : Glucose suppresses the activity of rat oxyntic histidine decarboxylase without affecting gastrin levels.

Pub. Date : 1997 Sep-Oct

PMID : 9361993






5 Functional Relationships(s)
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1 Glucose suppresses the activity of rat oxyntic histidine decarboxylase without affecting gastrin levels. Glucose histidine decarboxylase Rattus norvegicus
2 Glucose suppressed the activity of oxyntic mucosal histidine decarboxylase within 2 h when given either intragastrically or intraperitoneally to rats fasted for 24 h. Serum levels of gastrin, secretin, glucagon, and somatostatin and oxyntic mucosal levels of gastrin, histamine, and somatostatin showed no significant changes after glucose. Glucose histidine decarboxylase Rattus norvegicus
3 Glucose suppressed the activity of oxyntic mucosal histidine decarboxylase within 2 h when given either intragastrically or intraperitoneally to rats fasted for 24 h. Serum levels of gastrin, secretin, glucagon, and somatostatin and oxyntic mucosal levels of gastrin, histamine, and somatostatin showed no significant changes after glucose. Glucose histidine decarboxylase Rattus norvegicus
4 Glucose suppressed the aspirin-induced histidine decarboxylase activity without changing serum gastrin. Glucose histidine decarboxylase Rattus norvegicus
5 These results suggest that glucose acts directly on the enterochromaffin-like cells in rat oxyntic mucosa to suppress histidine decarboxylase activation. Glucose histidine decarboxylase Rattus norvegicus