Title : Diet, apoptosis, and carcinogenesis.

Pub. Date : 1997

PMID : 9361818






2 Functional Relationships(s)
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1 When grown in CD medium (5 microM or 0 microM choline) CWSV-1 rat hepatocytes immortalized with SV40 large T-antigen underwent p53-independent apoptosis (terminal dUTP end-labeling of fragmented DNA; laddering of DNA in agarose gel). Choline Wistar clone pR53P1 p53 pseudogene Rattus norvegicus
2 Our results indicate that acute withdrawal of choline induces p53-independent programmed cell death in hepatocytes, whereas cells adapted to survive in low choline are resistant to this form of apoptosis, as well as to cell death induced by TGF beta 1. Choline Wistar clone pR53P1 p53 pseudogene Rattus norvegicus