Pub. Date : 1997 Oct
PMID : 9349585
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Indeed, removal of the sialic acid or carbohydrate residues from native hCG transformed it into a thyroid stimulator that elicited a maximal response in terms of iodide uptake, organification and T3 secretion by human thyroid follicles as high as TSH and almost twice as high as native hCG. | N-Acetylneuraminic Acid | chorionic gonadotropin subunit beta 5 | Homo sapiens |
| 2 | Indeed, removal of the sialic acid or carbohydrate residues from native hCG transformed it into a thyroid stimulator that elicited a maximal response in terms of iodide uptake, organification and T3 secretion by human thyroid follicles as high as TSH and almost twice as high as native hCG. | N-Acetylneuraminic Acid | chorionic gonadotropin subunit beta 5 | Homo sapiens |
| 3 | hCG, and to a greater extent ds-hCG and dg-hCG, inhibited, as did TSH, gamma-interferon-induced human leukocyte antigen-DR (HLA-DR) expression in human thyrocytes, again reflecting the intrinsic thyrotropic activity of native hCG and its variants depleted of sialic acid or carbohydrate residues. | N-Acetylneuraminic Acid | chorionic gonadotropin subunit beta 5 | Homo sapiens |
| 4 | hCG, and to a greater extent ds-hCG and dg-hCG, inhibited, as did TSH, gamma-interferon-induced human leukocyte antigen-DR (HLA-DR) expression in human thyrocytes, again reflecting the intrinsic thyrotropic activity of native hCG and its variants depleted of sialic acid or carbohydrate residues. | N-Acetylneuraminic Acid | chorionic gonadotropin subunit beta 5 | Homo sapiens |
| 5 | hCG, and to a greater extent ds-hCG and dg-hCG, inhibited, as did TSH, gamma-interferon-induced human leukocyte antigen-DR (HLA-DR) expression in human thyrocytes, again reflecting the intrinsic thyrotropic activity of native hCG and its variants depleted of sialic acid or carbohydrate residues. | N-Acetylneuraminic Acid | chorionic gonadotropin subunit beta 5 | Homo sapiens |
| 6 | hCG, and to a greater extent ds-hCG and dg-hCG, inhibited, as did TSH, gamma-interferon-induced human leukocyte antigen-DR (HLA-DR) expression in human thyrocytes, again reflecting the intrinsic thyrotropic activity of native hCG and its variants depleted of sialic acid or carbohydrate residues. | N-Acetylneuraminic Acid | chorionic gonadotropin subunit beta 5 | Homo sapiens |
| 7 | The study was conducted in a serum-free culture system of human thyroid follicles and shows that removal of the sialic acid or carbohydrate residues from native hCG transform hCG variants into thyroid stimulating superagonists. | N-Acetylneuraminic Acid | chorionic gonadotropin subunit beta 5 | Homo sapiens |
| 8 | The study was conducted in a serum-free culture system of human thyroid follicles and shows that removal of the sialic acid or carbohydrate residues from native hCG transform hCG variants into thyroid stimulating superagonists. | N-Acetylneuraminic Acid | chorionic gonadotropin subunit beta 5 | Homo sapiens |