Pub. Date : 1997 Oct 24
PMID : 9341114
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Chloroquine extends the lifetime of the activated insulin receptor complex in endosomes. | Chloroquine | insulin receptor | Rattus norvegicus |
| 2 | Chloroquine treatment also increased the insulin receptor content of endosomes after insulin injection (integrated over 0-45 min) by 31% when compared with controls (p < 0.05). | Chloroquine | insulin receptor | Rattus norvegicus |
| 3 | Similarly, chloroquine increased both insulin receptor phosphotyrosine content and its exogenous tyrosine kinase activity after insulin injection (64%; p < 0.01 and 96% and p < 0. | Chloroquine | insulin receptor | Rattus norvegicus |
| 4 | These observations are consistent with the hypothesis that chloroquine-dependent inhibition of endosomal insulin receptor dissociation and subsequent degradation prolongs the half-life of the active endosomal receptor and potentiates insulin signaling from this compartment. | Chloroquine | insulin receptor | Rattus norvegicus |