Title : Altered regulation of cholesterol and cholesteryl ester synthesis in Chinese-hamster ovary cells overexpressing the oxysterol-binding protein is dependent on the pleckstrin homology domain.

Pub. Date : 1997 Aug 15

PMID : 9337870






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 CHO-OSBP cells showed a 40-60% decrease in acyl-CoA:cholesterol acyltransferase activity and mRNA, a 50% elevation in mRNA for three sterol-regulated genes [LDL receptor, 3-hydroxy-3-methylgluraryl (HMG)-CoA reductase and HMG-CoA synthase], and an 80% increase in [14C]acetate incorporation into cholesterol. Carbon-14 LOW QUALITY PROTEIN: oxysterol-binding protein 1 Cricetulus griseus