Title : Regulation of p53 by metal ions and by antioxidants: dithiocarbamate down-regulates p53 DNA-binding activity by increasing the intracellular level of copper.

Pub. Date : 1997 Oct

PMID : 9315628






1 Functional Relationships(s)
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1 In contrast, 1,10-orthophenanthroline, a cell-permeable chelator of Cu2+, promoted the redox activity of copper and up-regulated p53 DNA-binding activity through a DNA damage-dependent pathway. 1,10-orthophenanthroline tumor protein p53 Homo sapiens