Title : Potential metabolic bioactivation pathways involving cyclic tertiary amines and azaarenes.

Pub. Date : 1997 Sep

PMID : 9305573






1 Functional Relationships(s)
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1 The most dramatic illustration of this type of bioactivation process is the conversion of the parkinsonian-inducing neurotoxin MPTP (23) by brain MAO-B to the iminium (dihydropyridinium) metabolite 24 which is oxidized further to the pyridinium species MPP+ (25). pyridine monoamine oxidase B Homo sapiens