Title : Effects of thalidomide and related metabolites in a mouse corneal model of neovascularization.

Pub. Date : 1997 Jun

PMID : 9301478






3 Functional Relationships(s)
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1 Thalidomide, when administered orally, is an inhibitor of angiogenesis in the basic fibroblast growth factor (bFGF)-induced rabbit cornea micropocket assay. Thalidomide fibroblast growth factor 2 Mus musculus
2 We now show in the mouse that thalidomide given intraperitoneally but not orally significantly inhibits bFGF-induced and vascular endothelial growth factor (VEGF)-induced corneal neovascularization. Thalidomide fibroblast growth factor 2 Mus musculus
3 Experiments examining thalidomide"s enantiomers reveal-that the S(-)-enantiomer has the strongest antiangiogenic activity in VEGF-induced and bFGF-induced corneal neovascularization. Thalidomide fibroblast growth factor 2 Mus musculus