Pub. Date : 1997 Sep 9
PMID : 9283073
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Mapping conformational changes in a protein: application of a protein footprinting technique to cAMP-induced conformational changes in cAMP receptor protein. | Cyclic AMP | C-reactive protein | Homo sapiens |
2 | The binding of cAMP to CRP dramatically increases the specific DNA binding activity of the protein and, as has been previously shown, induces conformational changes in the protein. | Cyclic AMP | C-reactive protein | Homo sapiens |
3 | Binding of cAMP produced measurable differences in the susceptibility of CRP to the cleavage by Fe-EDTA. | Cyclic AMP | C-reactive protein | Homo sapiens |
4 | The F alpha-helix, which provides all base-specific contacts in the CRP-DNA complex, became hypersensitive to Fe-EDTA-mediated cleavage, whereas the solvent exposure of D and E alpha-helices was decreased upon binding of cAMP. | Cyclic AMP | C-reactive protein | Homo sapiens |
5 | These results suggest that a significant part of cAMP-induced conformational change in CRP involves a movement of secondary structure elements in the C-terminal domain of the protein so that the recognition F alpha-helix becomes exposed to the solvent. | Cyclic AMP | C-reactive protein | Homo sapiens |