Title : Biologically inactive growth hormone caused by an amino acid substitution.

Pub. Date : 1997 Sep 1

PMID : 9276733






1 Functional Relationships(s)
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1 Mutant GH was less potent than wild-type GH not only in phosphorylation of tyrosine residues in GHR, janus kinase 2 (JAK2), and signal transducers and activators of transcription 5 (STAT5) in IM-9 cells, but also in metabolic responses of BaF/GM cells, a stable clone transfected with cDNA of the chimera of the extracellular domain of human GHR, the transmembrane and the cytoplasmic domain of the human thrombopoietin receptor. Tyrosine growth hormone receptor Homo sapiens