Title : Affinity purification and kinetic analysis of mutant forms of yeast NAD+-specific isocitrate dehydrogenase.

Pub. Date : 1997 Aug 29

PMID : 9268311






1 Functional Relationships(s)
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1 In contrast, alanine replacement of the homologous Asp-286 and Ile-287 residues in IDH2 does not alter the allosteric response to AMP, but produces a 160-fold reduction in Vmax due to a 70-fold increase in the S0.5 value for NAD+. NAD isocitrate dehydrogenase (NAD(+)) IDH2 Saccharomyces cerevisiae S288C