Pub. Date : 1997 Jul
PMID : 9268231
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Monocrotaline (MCT) is bioactivated in liver cytochrome P-450s to MCT pyrrole (MCTP), which primarily injures the lung endothelium to result in the development of pulmonary hypertension (PH) in rats. | Monocrotaline | cytochrome P450, family 2, subfamily g, polypeptide 1 | Rattus norvegicus |
| 2 | Monocrotaline (MCT) is bioactivated in liver cytochrome P-450s to MCT pyrrole (MCTP), which primarily injures the lung endothelium to result in the development of pulmonary hypertension (PH) in rats. | Monocrotaline | cytochrome P450, family 2, subfamily g, polypeptide 1 | Rattus norvegicus |
| 3 | However, whether there is a relation between the degree of PH and the activity of liver cytochrome P-450 to convert MCT to MCTP remains unclear. | Monocrotaline | cytochrome P450, family 2, subfamily g, polypeptide 1 | Rattus norvegicus |