Title : Mutation (677 C to T) in the methylenetetrahydrofolate reductase gene aggravates hyperhomocysteinemia in hemodialysis patients.

Pub. Date : 1997 Aug

PMID : 9264011






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Elevated total homocysteine (tHcy) plasma levels can results from defective remethylation of Hcy to methionine due to decreased activity of the enzyme methylenetetrahydrofolate reductase (MTHFR). thcy methylenetetrahydrofolate reductase Homo sapiens
2 Elevated total homocysteine (tHcy) plasma levels can results from defective remethylation of Hcy to methionine due to decreased activity of the enzyme methylenetetrahydrofolate reductase (MTHFR). thcy methylenetetrahydrofolate reductase Homo sapiens
3 We tested the hypothesis that elevation of tHcy plasma levels in hemodialysis patients is influenced by the 677 C to T mutation of the MTHFR gene and examined the relation of the genotype with tHcy, folate and vitamin B12 plasma levels in these patients. thcy methylenetetrahydrofolate reductase Homo sapiens