Title : The p38/reactivating kinase mitogen-activated protein kinase cascade mediates the activation of the transcription factor insulin upstream factor 1 and insulin gene transcription by high glucose in pancreatic beta-cells.

Pub. Date : 1997 Aug 15

PMID : 9252422






1 Functional Relationships(s)
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1 The glucose-stimulated activation of IUF1 DNA binding and MAPKAP kinase-2 (but not the arsenite-induced activation of these proteins) was prevented by wortmannin and LY 294002 at concentrations similar to those that inhibit phosphatidylinositide 3-kinase. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one MAPK activated protein kinase 2 Homo sapiens