Title : Serine protease inhibitors block neutral sphingomyelinase activation, ceramide generation, and apoptosis triggered by daunorubicin.

Pub. Date : 1997 Jul

PMID : 9240970






1 Functional Relationships(s)
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1 Treatment of U937 and HL-60 cells with 0.5-1 microM of the chemotherapeutic drug daunorubicin induced a greater than 30% activation of neutral sphingomyelinase activity within 4-10 min with concomitant sphingomyelin hydrolysis and ceramide generation. Ceramides sphingomyelin phosphodiesterase 2 Homo sapiens