Title : Analysis of [C-11]alpha-methyl-tryptophan kinetics for the estimation of serotonin synthesis rate in vivo.

Pub. Date : 1997 Jun

PMID : 9236722






3 Functional Relationships(s)
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1 Analysis of [C-11]alpha-methyl-tryptophan kinetics for the estimation of serotonin synthesis rate in vivo. Serotonin RNA polymerase III subunit K Homo sapiens
2 We describe the tracer kinetic analysis of [C-11]-labeled alpha-methyl-tryptophan (AMT), an analogue of tryptophan, which has been developed as a tracer for serotonin synthesis using positron emission tomography (PET) in human brain. Serotonin RNA polymerase III subunit K Homo sapiens
3 These results indicate that the Patlak-plot method can be readily applied to [C-11]AMT data in order to create functional images of the K-complex, reflecting serotonin synthesis rate, within an acceptable error margin. Serotonin RNA polymerase III subunit K Homo sapiens