Pub. Date : 1997 May 15
PMID : 9210489
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | HNK-1 carbohydrate-mediated cell adhesion to laminin-1 is different from heparin-mediated and sulfatide-mediated cell adhesion. | Carbohydrates | beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P) | Mus musculus |
| 2 | The sulfated HNK-1 carbohydrate present on glycolipids and on several neural recognition molecules has been shown to mediate the adhesion of murine small cerebellar neurons and astrocytes to the extracellular matrix molecule laminin-1. | Carbohydrates | beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P) | Mus musculus |
| 3 | In this study, we characterized the binding of the HNK-1 carbohydrate to laminin-1 extracted from the Engelbreth-Holm-Swarm (EHS) sarcoma and distinguished it unequivocally from binding sites for other sulfated carbohydrates. | Carbohydrates | beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P) | Mus musculus |
| 4 | In this study, we characterized the binding of the HNK-1 carbohydrate to laminin-1 extracted from the Engelbreth-Holm-Swarm (EHS) sarcoma and distinguished it unequivocally from binding sites for other sulfated carbohydrates. | Carbohydrates | beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P) | Mus musculus |
| 5 | The HNK-1 carbohydrate also interacted with placental laminin isoforms containing an alpha chain variant. | Carbohydrates | beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P) | Mus musculus |
| 6 | Binding studies with native or denatured laminin E8 fragments and proteolytic or recombinant fragments of the G domain localized the HNK-1 carbohydrate binding site to domain G2. | Carbohydrates | beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P) | Mus musculus |
| 7 | The G2 domain is also involved in the adhesion of HNK-1 carbohydrate expressing early postnatal cerebellar neurons and is different from heparin- and sulfatide-mediated cell adhesion to laminin-1. | Carbohydrates | beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P) | Mus musculus |
| 8 | HNK-1 carbohydrate-mediated cell adhesion appears, however, to be dependent on the native conformation of laminin-1 indicating a more complex cellular recognition process. | Carbohydrates | beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P) | Mus musculus |