Title : Expression of mixed lineage kinase-1 in pancreatic beta-cell lines at different stages of maturation and during embryonic pancreas development.

Pub. Date : 1997 Jun 27

PMID : 9195943






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Antisense oligonucleotides to two distinct regions of MLK-1 caused RIN-5AH cells, but not RIN-A12 cells, to adopt a highly undifferentiated morphology, with a reduction in DNA synthesis and MLK-1 protein levels and elevated glucagon mRNA levels, but with no effect on insulin mRNA. Oligonucleotides mitogen-activated protein kinase kinase kinase 9 Rattus norvegicus
2 Antisense oligonucleotides to two distinct regions of MLK-1 caused RIN-5AH cells, but not RIN-A12 cells, to adopt a highly undifferentiated morphology, with a reduction in DNA synthesis and MLK-1 protein levels and elevated glucagon mRNA levels, but with no effect on insulin mRNA. Oligonucleotides mitogen-activated protein kinase kinase kinase 9 Rattus norvegicus