Title : Endothelial barrier dysfunction and p42 oxidation induced by TNF-alpha are mediated by nitric oxide.

Pub. Date : 1997 May

PMID : 9176264






2 Functional Relationships(s)
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1 PAEM were incubated with TNF-alpha (100 U/ml) for 4 h. Incubation of PAEM with TNF-alpha resulted in increases in 1) the .NO oxidation product nitrite (NO2-), 2) nitrotyrosine immunofluorescence, 3) the oxidation of p42 (tentatively identified as actin), and 4) permeability to Evans blue dye-albumin. Nitrites tumor necrosis factor Homo sapiens
2 PAEM were incubated with TNF-alpha (100 U/ml) for 4 h. Incubation of PAEM with TNF-alpha resulted in increases in 1) the .NO oxidation product nitrite (NO2-), 2) nitrotyrosine immunofluorescence, 3) the oxidation of p42 (tentatively identified as actin), and 4) permeability to Evans blue dye-albumin. Nitrites tumor necrosis factor Homo sapiens