Title : Spontaneous DNA lesions poison human topoisomerase IIalpha and stimulate cleavage proximal to leukemic 11q23 chromosomal breakpoints.

Pub. Date : 1997 May 20

PMID : 9166762






2 Functional Relationships(s)
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Protein Name
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1 Topoisomerase II-targeted drugs, such as etoposide, "poison" this enzyme and kill cells by increasing levels of covalent topoisomerase II-cleaved DNA complexes. Etoposide Topoisomerase 2 Drosophila melanogaster
2 Topoisomerase II-targeted drugs, such as etoposide, "poison" this enzyme and kill cells by increasing levels of covalent topoisomerase II-cleaved DNA complexes. Etoposide Topoisomerase 2 Drosophila melanogaster