Pub. Date : 1997 May
PMID : 9161608
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Ethanol and its metabolite acetaldehyde have been shown to stimulate immunoreactive beta-endorphin (IR-beta-EP) secretion from hypothalamic neurons in primary cultures. | Acetaldehyde | proopiomelanocortin | Homo sapiens |
| 2 | Ethanol and its metabolite acetaldehyde have been shown to stimulate immunoreactive beta-endorphin (IR-beta-EP) secretion from hypothalamic neurons in primary cultures. | Acetaldehyde | proopiomelanocortin | Homo sapiens |
| 3 | Acetaldehyde stimulated IR-beta-EP secretion from this culture for a period of 48 hr, but the IR-beta-EP secretory response to acetaldehyde reduced gradually with time during the first 48-hr period and reached the basal level at 72 hr. | Acetaldehyde | proopiomelanocortin | Homo sapiens |
| 4 | Acetaldehyde stimulated IR-beta-EP secretion from this culture for a period of 48 hr, but the IR-beta-EP secretory response to acetaldehyde reduced gradually with time during the first 48-hr period and reached the basal level at 72 hr. | Acetaldehyde | proopiomelanocortin | Homo sapiens |
| 5 | However, reduced IR- beta-EP secretory response to acetaldehyde with time was associated with the time-dependent increase in cell death. | Acetaldehyde | proopiomelanocortin | Homo sapiens |
| 6 | These results suggest that (i) chronic treatment with ethanol desensitizes beta-EP-secreting neurons due to reduced cellular functions and (ii) chronic acetaldehyde reduces beta-EP neurotransmission due to cell death. | Acetaldehyde | proopiomelanocortin | Homo sapiens |