Title : Evidence that complex formation by Bas1p and Bas2p (Pho2p) unmasks the activation function of Bas1p in an adenine-repressible step of ADE gene transcription.

Pub. Date : 1997 Jun

PMID : 9154826






9 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Evidence that complex formation by Bas1p and Bas2p (Pho2p) unmasks the activation function of Bas1p in an adenine-repressible step of ADE gene transcription. Adenine Pho2p Saccharomyces cerevisiae S288C
2 Evidence that complex formation by Bas1p and Bas2p (Pho2p) unmasks the activation function of Bas1p in an adenine-repressible step of ADE gene transcription. Adenine Pho2p Saccharomyces cerevisiae S288C
3 Bas1p and Bas2p (Pho2p) are Myb-related and homeodomain DNA binding proteins, respectively, required for transcription of adenine biosynthetic genes in Saccharomyces cerevisiae. Adenine Pho2p Saccharomyces cerevisiae S288C
4 Bas1p and Bas2p (Pho2p) are Myb-related and homeodomain DNA binding proteins, respectively, required for transcription of adenine biosynthetic genes in Saccharomyces cerevisiae. Adenine Pho2p Saccharomyces cerevisiae S288C
5 A LexA-Bas2p fusion protein was found to activate transcription from a lexAop-lacZ reporter independently of both BAS1 function and the adenine levels in the medium. Adenine Pho2p Saccharomyces cerevisiae S288C
6 The activation functions of both authentic Bas1p and LexA-Bas1p were stimulated under adenine-repressing conditions by overexpression of Bas2p, suggesting that complex formation by these proteins is inhibited in adenine-replete cells. Adenine Pho2p Saccharomyces cerevisiae S288C
7 The activation functions of both authentic Bas1p and LexA-Bas1p were stimulated under adenine-repressing conditions by overexpression of Bas2p, suggesting that complex formation by these proteins is inhibited in adenine-replete cells. Adenine Pho2p Saccharomyces cerevisiae S288C
8 From these results we propose that complex formation between Bas1p and Bas2p unmasks a latent activation function in Bas1p as a critical adenine-regulated step in transcription of the ADE genes. Adenine Pho2p Saccharomyces cerevisiae S288C
9 From these results we propose that complex formation between Bas1p and Bas2p unmasks a latent activation function in Bas1p as a critical adenine-regulated step in transcription of the ADE genes. Adenine Pho2p Saccharomyces cerevisiae S288C