Title : Synergistic interaction between endothelium-derived NO and prostacyclin in pulmonary artery: potential role for K+ATP channels.

Pub. Date : 1997 May

PMID : 9154337






3 Functional Relationships(s)
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1 Relaxations to low concentrations of bradykinin and A23187 were abolished by combined inhibition of NO-synthase (by N omega-nitro-L-arginine methyl ester L-NAME, 30 microM) and cyclo-oxygenase (indomethacin, 10 microM), suggesting mediation by NO and PGI2. NG-Nitroarginine Methyl Ester kininogen 1 Canis lupus familiaris
2 Relaxations to low concentrations of bradykinin and A23187 were abolished by combined inhibition of NO-synthase (by N omega-nitro-L-arginine methyl ester L-NAME, 30 microM) and cyclo-oxygenase (indomethacin, 10 microM), suggesting mediation by NO and PGI2. NG-Nitroarginine Methyl Ester kininogen 1 Canis lupus familiaris
3 At high concentrations, bradykinin, A23187 or acetylcholine caused endothelium-dependent relaxation that was insensitive to L-NAME + indomethacin. NG-Nitroarginine Methyl Ester kininogen 1 Canis lupus familiaris